Description
Product Characteristics:
Aliases: GDNF family receptor alpha 2 antibody, GDNF family receptor alpha-2 antibody, GDNF receptor alpha-2 antibody, GDNF receptor beta antibody, GDNFR beta antibody, GDNFR-alpha-2 antibody, GDNFR-beta antibody, GDNFRB antibody, GFR alpha 2 antibody, GFR-alpha-2 antibody, GFRA 2 antibody, Gfra2 antibody, GFRA2_HUMAN antibody, Glial cell line derived neurotrophic factor family receptor alpha2b antibody, Glial cell line derived neurotrophic factor receptor beta antibody, Neurturin receptor alpha antibody, NRTNR alpha antibody, NRTNR-alpha antibody, NTNR alpha antibody, NTNR-alpha antibody, NTNRA antibody, PI linked cell surface accessory protein antibody, PI linked cell-surface accessory protein antibody, RET ligand 2 antibody, RETL 2 antibody, RETL2 antibody, TGF beta related neurotrophic factor receptor 2 antibody, TGF-beta-related neurotrophic factor receptor 2 antibody, TRN receptor GPI anchored antibody, TRNR 2 antibody, TRNR2 antibody
Target Information: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]